Changes in blink reflex excitability after globus pallidus internus stimulation for dystonia
Identifieur interne : 003539 ( Main/Exploration ); précédent : 003538; suivant : 003540Changes in blink reflex excitability after globus pallidus internus stimulation for dystonia
Auteurs : Stephen Tisch [Royaume-Uni] ; Patricia Limousin [Royaume-Uni] ; John C. Rothwell [Royaume-Uni] ; Peter Asselman [Royaume-Uni] ; Niall Quinn [Royaume-Uni] ; Marjan Jahanshahi [Royaume-Uni] ; Kailash P. Bhatia [Royaume-Uni] ; Marwan Hariz [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-10.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Blinking (physiology), Deep Brain Stimulation, Deep brain stimulation, Dominance, Cerebral (physiology), Dystonia, Dystonia Musculorum Deformans (physiopathology), Dystonia Musculorum Deformans (therapy), Electromyography, Excitability, Female, Globus Pallidus (physiopathology), Humans, Male, Middle Aged, Nervous system diseases, Neural Inhibition (physiology), Palpebral reflex, Reference Values, Treatment Outcome, blink vellex, deep brain stimulation, dystonia.
- MESH :
- physiology : Blinking, Dominance, Cerebral, Neural Inhibition.
- physiopathology : Dystonia Musculorum Deformans, Globus Pallidus.
- therapy : Dystonia Musculorum Deformans.
- Adult, Deep Brain Stimulation, Electromyography, Female, Humans, Male, Middle Aged, Reference Values, Treatment Outcome.
Abstract
A pathophysiological feature of dystonia is reduced inhibition at various levels of the nervous system, which may be detected in clinically unaffected body parts. Chronic deep brain stimulation (DBS) of the globus pallidus internus (GPi) has emerged as an effective treatment for primary torsion dystonia (PTD), although its mechanism of action and impact on inhibitory abnormalities in dystonia are unknown. We sought to understand the effect of GPi DBS on brainstem excitability in patients with PTD. We measured the blink reflex from orbicularis oculi in response to paired electrical stimulation of the supraorbital nerve at interstimulus intervals of 500 and 1,000 milliseconds in 10 patients with PTD before and at intervals of 1, 3, and 6 months after bilateral GPi DBS and in 10 healthy subjects. Patients were clinically evaluated using the Burke–Fahn–Marsden dystonia rating scale. We found R2 inhibition was significantly decreased in PTD patients compared with control subjects and progressively increased after GPi DBS, which correlated with clinical improvement in dystonia. We conclude that GPi DBS for PTD results in functional reorganization of the nervous system, which includes a long‐term increase in brainstem inhibition. © 2006 Movement Disorder Society
Url:
DOI: 10.1002/mds.20899
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-10">2006-10</date><biblScope unit="vol">21</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1650">1650</biblScope><biblScope unit="page" to="1655">1655</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">2F53BA8D72605CC7A209EE972EA2944393F922B6</idno><idno type="DOI">10.1002/mds.20899</idno><idno type="ArticleID">MDS20899</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Blinking (physiology)</term><term>Deep Brain Stimulation</term><term>Deep brain stimulation</term><term>Dominance, Cerebral (physiology)</term><term>Dystonia</term><term>Dystonia Musculorum Deformans (physiopathology)</term><term>Dystonia Musculorum Deformans (therapy)</term><term>Electromyography</term><term>Excitability</term><term>Female</term><term>Globus Pallidus (physiopathology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Neural Inhibition (physiology)</term><term>Palpebral reflex</term><term>Reference Values</term><term>Treatment Outcome</term><term>blink vellex</term><term>deep brain stimulation</term><term>dystonia</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blinking</term><term>Dominance, Cerebral</term><term>Neural Inhibition</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonia Musculorum Deformans</term><term>Globus Pallidus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Dystonia Musculorum Deformans</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Deep Brain Stimulation</term><term>Electromyography</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reference Values</term><term>Treatment Outcome</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term><term>Excitabilité</term><term>Réflexe palpébral</term><term>Stimulation cérébrale profonde</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A pathophysiological feature of dystonia is reduced inhibition at various levels of the nervous system, which may be detected in clinically unaffected body parts. Chronic deep brain stimulation (DBS) of the globus pallidus internus (GPi) has emerged as an effective treatment for primary torsion dystonia (PTD), although its mechanism of action and impact on inhibitory abnormalities in dystonia are unknown. We sought to understand the effect of GPi DBS on brainstem excitability in patients with PTD. We measured the blink reflex from orbicularis oculi in response to paired electrical stimulation of the supraorbital nerve at interstimulus intervals of 500 and 1,000 milliseconds in 10 patients with PTD before and at intervals of 1, 3, and 6 months after bilateral GPi DBS and in 10 healthy subjects. Patients were clinically evaluated using the Burke–Fahn–Marsden dystonia rating scale. We found R2 inhibition was significantly decreased in PTD patients compared with control subjects and progressively increased after GPi DBS, which correlated with clinical improvement in dystonia. We conclude that GPi DBS for PTD results in functional reorganization of the nervous system, which includes a long‐term increase in brainstem inhibition. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Tisch, Stephen" sort="Tisch, Stephen" uniqKey="Tisch S" first="Stephen" last="Tisch">Stephen Tisch</name></region><name sortKey="Asselman, Peter" sort="Asselman, Peter" uniqKey="Asselman P" first="Peter" last="Asselman">Peter Asselman</name><name sortKey="Bhatia, Kailash P" sort="Bhatia, Kailash P" uniqKey="Bhatia K" first="Kailash P." last="Bhatia">Kailash P. Bhatia</name><name sortKey="Hariz, Marwan" sort="Hariz, Marwan" uniqKey="Hariz M" first="Marwan" last="Hariz">Marwan Hariz</name><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><name sortKey="Limousin, Patricia" sort="Limousin, Patricia" uniqKey="Limousin P" first="Patricia" last="Limousin">Patricia Limousin</name><name sortKey="Quinn, Niall" sort="Quinn, Niall" uniqKey="Quinn N" first="Niall" last="Quinn">Niall Quinn</name><name sortKey="Rothwell, John C" sort="Rothwell, John C" uniqKey="Rothwell J" first="John C." last="Rothwell">John C. Rothwell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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